참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | 5-Chloro-2-nitroaniline | HCID 74218 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-(4-Methylpiperazin-1-yl)-2-nitroaniline | HCID 2760034 | 54.4% |
반응 단계
A mixture of 5-chloro-2-nitrophenylamine (2.5 g, 14 mmol), 1-methylpiperizine (3.2 mL, 30 mmol), and potassium carbonate (K2CO3) (2.0 g, 14 mmol) in dimethylformamide (DMF) (20 mL) was stirred at 120° C. for 18 h. The reaction mixture was cooled to room temperature and poured into water (150 mL). The precipitated crude product was collected by filtration, dried in vacuo, and purified by recrystallization from ethyl acetate (EtOAc) (75 mL) to yield yellow-green crystals (1.8 g, 54%). See, J. Med. Chem., 39:997 (1996).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07179912B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_02 |
|---|
| ORD ID | ord-c5e3e4baf23b4f81ac13c108ef84a414 |
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| 출처 메모 | uspto-grants-2007_02 |
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