참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Chloro-2-nitroaniline | HCID 74218 | — |
| 반응물 | N-(2-Methoxyphenyl)piperazine hydrochloride | HCID 9899402 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 10268333 | HCID 10268333 | — |
반응 단계
A mixture of 5-chloro-2-nitrophenylamine (1.3 g, 7.0 mmol), 1-(2-methoxyphenyl)-piperazine hydrochloride (5.0 g, 20 mmol), and K2CO3 (4.0 g, 29 mmol) in DMF (20 mL) was stirred at 110° C. for 18 h. The reaction mixture was cooled to room temperature and poured into water (200 mL). The crude solid product was collected by filtration, air dried, and purified by trituration with CHCl3 (1.3 g, 57%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07179912B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_02 |
|---|
| ORD ID | ord-579e613bfeb34d5e8b55a1c38dc40bb2 |
|---|
| 출처 메모 | uspto-grants-2007_02 |
|---|
