2-Hydroxy-4-morpholin-4-yl-benzaldehyde → 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)-propan-1-one

HRID 349674

반응식

HRID 349674 반응식
[N:1]1([C:7]2[CH:8]=[C:9]([OH:15])[C:10](=[CH:13][CH:14]=2)[CH:11]=[O:12])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:16]([Mg]Br)[CH3:17]>>[OH:15][C:9]1[CH:8]=[C:7]([N:1]2[CH2:2][CH2:3][O:4][CH2:5][CH2:6]2)[CH:14]=[CH:13][C:10]=1[C:11](=[O:12])[CH2:16][CH3:17]

참가 물질

3

반응물 2

HCID 98156592-Hydroxy-4-morpholin-4-yl-benzaldehydeHCID 178418443HCID 178418443, 화합물

생성물 1

HCID 99646891-(2-Hydroxy-4-morpholin-4-yl-phenyl)-propan-1-one

실험 절차

Following the procedure for preparing Example 34, 4-(4-morpholinyl)-salicylaldehyde (1.0 g, 5 mmol) and ethylmagnesium bromide (1.0 M solution in tetrahydrofuran, 11 mL, 11 mmol) were converted to the product (208 mg, 18%).

출처 및 근거

ORD 기록
ord-c2724d3583464f398d8246c235623b68
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179912B2

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