2-Hydroxy-4-morpholin-4-yl-benzaldehyde → DNA-PK inhibitor V

반응식

[N:1]1([C:7]2[CH:8]=[C:9]([OH:15])[C:10](=[CH:13][CH:14]=2)[CH:11]=[O:12])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:16]1([Li])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[OH:15][C:9]1[CH:8]=[C:7]([N:1]2[CH2:2][CH2:3][O:4][CH2:5][CH2:6]2)[CH:14]=[CH:13][C:10]=1[C:11]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:12]

참가 물질

반응물 2

HCID 98156592-Hydroxy-4-morpholin-4-yl-benzaldehyde

HCID 178506676HCID 178506676, 화합물

생성물 1

HCID 16760391DNA-PK inhibitor V

실험 절차

Following the procedure for preparing Example 34, 4-(4-morpholinyl)-salicylaldehyde (1.0 g, 5 mmol) and phenyllithium (1.8 M solution in tetrahydrofuran, 6.0 mL, 11 mmol) were converted to the product (387 mg, 28%).

출처 및 근거

ORD 기록: ord-92fbd71d2c884614a45071d181fe2c05
출처 데이터셋: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07179912B2

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