5-Morpholino-2-nitroaniline → 4-(Morpholin-4-yl)benzene-1,2-diamine
반응식
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]([N+:14]([O-])=O)=[C:11]([NH2:13])[CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H][H]>C(O)(=O)C.C(O)C.[Pd]>[N:1]1([C:7]2[CH:12]=[C:11]([NH2:13])[C:10]([NH2:14])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1참가 물질
6
실험 절차
A solution of 5-morpholin-4-yl-2-nitro-phenylamine (4.0 g, 0.02 mol) in acetic acid (100 mL) and ethanol (100 mL) was treated with hydrogen gas (60 psi) for 30 min in the presence of palladium on carbon catalyst (0.5 g, 10% Pd). The catalyst was removed by filtration through CELITE®, and the filtrate was concentrated to a syrup and dried in vacuo to afford the intermediate 4-morpholin-4-yl-benzene-1,2-diamine as a crude green solid (3.2 g).
후처리
- customThe catalyst was removed by filtration through CELITE®
- concentrationthe filtrate was concentrated to a syrup
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-ac74ca14d2064a72aa4797f9e7d3f434
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07179912B2
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