4-(3-Nitrophenyl)morpholine → 3-(Morpholin-4-yl)aniline

HRID 349699노트

반응식

HRID 349699 반응식
[N:1]1([C:7]2[CH:8]=[C:9]([N+:13]([O-])=O)[CH:10]=[CH:11][CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>CO.O1CCCC1.O>[N:1]1([C:7]2[CH:8]=[C:9]([NH2:13])[CH:10]=[CH:11][CH:12]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

참가 물질

3

반응물 1

HCID 12532734-(3-Nitrophenyl)morpholine

생성물 1

HCID 8477683-(Morpholin-4-yl)aniline수율 85.3%

시약·촉매·용매 1

HCID 21892291Methanol tetrahydrofuran water용매

실험 절차

A 500 mL roundbottom flask equipped with stir bar and 3-way stopcock charged with MeOH/tetrahydrofuran/water (200 mL of 2:1:1) was purged thoroughly with nitrogen. To this was added 1.0 g of 10% Pd/C followed by addition of 10 g (48.0 mmol) of 3-morpholinyl nitrobenzene. The mixture then was stirred under a hydrogen atmosphere for 4 days (1 atm). The reaction was filtered over GF/F filter paper and the filtrate concentrated in vacuo to remove MeOH and THF. The resulting solid was recovered by filtration, washed with water, air dried, then dried in vacuo to give 7.3 g (83% yield) of the desired aniline as beige crystals.

후처리

  1. customA 500 mL roundbottom flask equipped
  2. customwas purged thoroughly with nitrogen
  3. additionTo this was added 1.0 g of 10% Pd/C
  4. stirringThe mixture then was stirred under a hydrogen atmosphere for 4 days (1 atm)
  5. filtrationThe reaction was filtered over GF/F
  6. filtrationfilter paper
  7. concentrationthe filtrate concentrated in vacuo
  8. customto remove MeOH and THF
  9. filtrationThe resulting solid was recovered by filtration
  10. washwashed with water, air
  11. customdried
  12. customdried in vacuo

출처 및 근거

ORD 기록
ord-538846cd2b8245489c44f2a9a5fb8c6d
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179912B2

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