Thionyl Chloride → 4-[(2-methylbenzoyl)amino]benzoyl Chloride

HRID 3497

반응식

HRID 3497 반응식
[CH3:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11](O)=[O:12])=[CH:9][CH:8]=1)=[O:5].S(Cl)([Cl:22])=O>>[CH3:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([Cl:22])=[O:12])=[CH:9][CH:8]=1)=[O:5]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 116158144-[(2-methylbenzoyl)amino]benzoic Acid

생성물 1

HCID 107074414-[(2-methylbenzoyl)amino]benzoyl Chloride

실험 절차

A mixture of 10.3 g of 4-[(2-methylbenzoyl)amino]benzoic acid and 32 ml of thionyl chloride is refluxed for 1.5 hours. The solution is concentrated in vacuo. Toluene is added and the solvent removed in vacuo. Toluene is added and the mixture chilled and filtered to give the desired product as a yellow solid, 135°-141° C.

후처리

  1. temperatureis refluxed for 1.5 hours
  2. concentrationThe solution is concentrated in vacuo
  3. additionToluene is added
  4. customthe solvent removed in vacuo
  5. additionToluene is added
  6. temperaturethe mixture chilled
  7. filtrationfiltered

출처 및 근거

ORD 기록
ord-c6a9d24539574639bdbc2294d2722940
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733905

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