참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 반응물 | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Methyl 2-amino-4-fluorobenzoate | HCID 14075433 | — |
반응 단계
To a cooled (0° C.), stirred solution of 4-fluoro-2-aminobenzoic acid (2.68 g; 17.3 mmol) in dry tetrahydrofuran (60 mL) and MeOH (10 mL) was added a solution of trimethylsilyldiazomethane in hexanes (12 mL of 2.0 N; 24 mmol) via syringe over 20 minutes under nitrogen atmosphere. The resulting solution was allowed to warm to room temperature and stirred for 2 hours then concentrated in vacuo to provide the ester a light yellow solid (˜100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07179912B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_02 |
|---|
| ORD ID | ord-5baa302909564323a9d46e230fd0734e |
|---|
| 출처 메모 | uspto-grants-2007_02 |
|---|
