Oxalyl chloride → 2-Chloro-4,5-difluorobenzoyl Isocyanate

HRID 349728

반응식

HRID 349728 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:14](Cl)=[O:15]>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([N:6]=[C:14]=[O:15])=[O:5]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 23171512-Chloro-4,5-difluorobenzamide

생성물 1

HCID 115575832-Chloro-4,5-difluorobenzoyl Isocyanate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-Chloro-4,5-difluorobenzamide was dissolved in dichloromethane, admixed with 1.5 eq. of oxalyl chloride and heated to reflux for 16 hours. The reaction mixture was concentrated under high vacuum and reacted in stage b without further purification.

후처리

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. concentrationThe reaction mixture was concentrated under high vacuum
  4. customreacted in stage b without further purification

출처 및 근거

ORD 기록
ord-37b2489659b54d3c86a3d1c2a4eced91
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179941B2

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