5-Bromopentanenitrile → HCID 178439672, 화합물

HRID 34976노트

반응식

HRID 34976 반응식
[CH2:1]([C:4]1[C:10]([OH:11])=[CH:9][CH:8]=[CH:7][C:5]=1[OH:6])[CH2:2][CH3:3].Br[CH2:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18].[N-:19]=[N+:20]=[N-:21].CN(C)C(=[NH2+])N(C)C>CN(C)C=O>[CH2:1]([C:4]1[C:5]([OH:6])=[CH:7][CH:8]=[CH:9][C:10]=1[O:11][CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[NH:18][N:21]=[N:20][N:19]=1)[CH2:2][CH3:3]

참가 물질

5

반응물 3

HCID 794355-BromopentanenitrileHCID 2620601,3-Benzenediol, propyl-HCID 178484365HCID 178484365, 화합물

생성물 1

HCID 178439672HCID 178439672, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Six grams of 2-propylresorcinol and 6.4 g. of 5-bromovaleronitrile were reacted following cedure of Example 2A to provide 3.4 g. of the desired nitrile intermediate. This intermediate was heated to 125° C. overnight with 40 mmoles of tetramethylguanidinium azide in 10 ml. of dimethylformamide. The solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate. The organic solution was washed with water adjusted to pH 6. The organic layer was dried and evaporated to yield the desired subtitle tetrazole intermediate which crystallized after evaporation of the solvent. NMR.

후처리

  1. customto provide 3.4 g
  2. customThe solvent was removed under reduced pressure
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. washThe organic solution was washed with water
  5. customThe organic layer was dried
  6. customevaporated

출처 및 근거

ORD 기록
ord-06cd2fb2963b4f3c9f8a55e07e3e2ef8
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764521

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