Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Atropic acid → 3-[4-(Tert-butoxycarbonyl)piperazino]-2-phenylpropanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Atropic acid | HCID 68114 | — |
| 반응물 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 3-[4-(Tert-butoxycarbonyl)piperazino]-2-phenylpropanoic acid | HCID 45588421 | 54.3% |
반응 단계
Piperazine-1-carboxylic acid tert-butyl ester (17.43 g) and 2-phenylacrylic acid (18 g) in iso-propanol (500 ml) was heated at reflux for four days. The resulting precipitate was filtered, washed with diethyl ether and dried under vacuum to give the title compound as a white solid (17 g; MS: APCI+(M+H) 335).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07179922B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-908250ec0eec43b19824e226329ee85a |
| 출처 메모 | uspto-grants-2007_02 |