Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 5-Methanesulfonyl-1H-indole-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | Methyl 5-(methylsulfonyl)-1H-indole-2-carboxylate | HCID 735868 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-Methanesulfonyl-1H-indole-2-carboxylic acid | HCID 22394446 | 23.8% |
반응 단계
To a solution of the 5-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester (0.49 g) in THF (12 mL) and water (4 ml) was added LiOH (0.098 g). The reaction mixture was left to stir for 2 hours. Acetic acid was added and the product extracted with dichloromethane. The organic extracts were combined, dried with magnesium sulfate, filtered and the filtrate evaporated to give the title compound as a solid (0.110 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07179922B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-59bd6241b13b4cf58ff933b7a25a70c8 |
| 출처 메모 | uspto-grants-2007_02 |