Potassium Iodide → HCID 21297287, 화합물

HRID 34978

반응식

HRID 34978 반응식
[CH2:1]([C:4]1[C:9]([Cl:10])=[C:8]([Cl:11])[CH:7]=[CH:6][C:5]=1[OH:12])[CH2:2][CH3:3].Br[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(C(C)=O)C>[CH2:1]([C:4]1[C:9]([Cl:10])=[C:8]([Cl:11])[CH:7]=[CH:6][C:5]=1[O:12][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21])[CH2:2][CH3:3]

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 1217237-Bromoheptanoic acidHCID 6003603,4-Dichloro-2-propylphenol

생성물 1

HCID 21297287HCID 21297287, 화합물

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A solution of 3.09 g. of 2-propyl-3,4-dichlorophenol, 3.1 g. of 7-bromoheptanoic acid, 3.1 g. of potassium carbonate, and 2.0 g. of potassium iodide in 50 ml. of methyl ethyl ketone was heated at reflux overnight. The reaction mixture was cooled to room temperature and evaporated in vacuo. Ethyl acetate and water were added to the residue and the layers were separated. Fresh water was added to the organic layer, the pH was adjusted to 2.0 with acid, and the layers were separated. The organic layer was washed with a saturated sodium chloride solution, filtered through sodium sulfate, and evaporated to dryness to give 4.68 g. of the desired title product.

후처리

  1. temperatureat reflux overnight
  2. customevaporated in vacuo
  3. additionEthyl acetate and water were added to the residue
  4. customthe layers were separated
  5. additionFresh water was added to the organic layer
  6. customthe layers were separated
  7. washThe organic layer was washed with a saturated sodium chloride solution
  8. filtrationfiltered through sodium sulfate
  9. customevaporated to dryness
  10. customto give 4.68 g

출처 및 근거

ORD 기록
ord-310b7c0479814ee9878d944c0f91516a
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764521

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