Triethylamine → 3-(2-Methyl-pent-2-enoyl)-4-phenyl-oxazolidin-2-one

HRID 349823

반응식

HRID 349823 반응식
F[C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10]C(O)=O.[CH3:14][C:15]([CH3:20])(C)[C:16](Cl)=[O:17].[Li+].[Cl-].C[C@H]1[C@@H](C2C=CC=CC=2)[O:27][C:26](=[O:35])[NH:25]1.[CH2:36](N(CC)CC)[CH3:37]>C1COCC1>[CH3:14][C:15](=[CH:20][CH2:36][CH3:37])[C:16]([N:25]1[CH:9]([C:3]2[CH:2]=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH2:10][O:35][C:26]1=[O:27])=[O:17]

참가 물질

7

반응물 5

HCID 8471TriethylamineHCID 62493Pivaloyl chlorideHCID 433294Lithium ChlorideHCID 8531614-Methyl-5-phenyl-2-oxazolidinone, (4S,5R)-HCID 49863953-(2,4-difluorophenyl)propanoic Acid

생성물 1

HCID 690482483-(2-Methyl-pent-2-enoyl)-4-phenyl-oxazolidin-2-one수율 99%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

A flask was charged with 29.5 g (158 mmol) of 3-(2,4-difluoro-phenyl)-propionic acid, 700 mL of THF, and 82.8 mL of triethylamine. The mixture was cooled to 0° C. and 23.4 mL of trimethyl acetyl chloride was added slowly. The mixture was stirred cold for 1 hour. Then 8.06 g (190 mmol) of LiCl and 28.1 g of (4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one was added. The mixture was allowed to warm room temperature and stirred overnight. The solids were filtered off, and the solvent was removed under reduced pressure. The residue was taken up in diethyl ether and washed with sat. aq. ammonium chloride, sat. aq. sodium bicarbonate, and the solvent were removed under reduced pressure. The crude residue was purified by column chromatography (3:1 dichloromethane/hexanes eluent) to give 54 g (99% yield) of the titled compound.

후처리

  1. temperatureto warm room temperature
  2. stirringstirred overnight
  3. filtrationThe solids were filtered off
  4. customthe solvent was removed under reduced pressure
  5. washwashed with sat. aq. ammonium chloride, sat. aq. sodium bicarbonate
  6. customthe solvent were removed under reduced pressure
  7. customThe crude residue was purified by column chromatography (3:1 dichloromethane/hexanes eluent)

출처 및 근거

ORD 기록
ord-b24b07d8b7dc45fb9b56dd08ab118735
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179934B2

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