Dimethyl Sulfide → (4S,5R)-3-((2R,3R)-2,3-Dimethyl-hexanoyl)-4,5-diphenyl-oxazolidin-2-one

A 22 L 4-neck round bottom flask was equipped with an addition funnel, mechanical stirrer, and nitrogen inlet. The system was purged with nitrogen for 1 hour. THF (6 L) were charged to the flask followed by 1236 g (6.01 mol) of CuBr.S(CH3)2 and 364 g (8.59 mol) of LiCl. The reaction was stirred for 15 minutes at ambient temperature. The solution was cooled to −35° C. and 3.96 L (11.88 mol) of a 3M solution of CH3MgCl in THF was charged at a rate as to keep the internal temperature of the reaction mixture below −25° C. The reaction was stirred for 1 hour after the addition of CH3MgCl was complete. (4S,5R)-3-((E)-2-Methyl-hex-2-enoyl)-4,5-diphenyl-oxazolidin-2-one (1.00 Kg, 2.86 mol) was added as a solid in one portion and the reaction was stirred at −30° C. for 4 hours. The reaction mixture was transferred over a 2 hour period into another 22 L flask equipped with a mechanical stirrer, transfer line, vacuum line, and containing 4 L of 1:1 acetic acid:THF solution cooled in an ice-water bath. The quenched solution was stirred for 30 minutes and then diluted with 4 L of 2M NH4OH in saturated aqueous NH4Cl and 2 L of water. The biphasic mixture was stirred for 15 minutes and the phases separated. The organic phase was washed 4× with 4 L aliquots of the 2M NH4OH solution. No more blue color was observed in the washes or the organic phase so the organic phase was diluted with 8 L of water and the THF was distilled off until the internal temperature of the distillation pot reached 95° C. The suspension was cooled to ambient temperature and filtered. The solids were washed with 4 L of water and suction dried to give 868.2 g of an off white solid. This material was recrystallized from 2 L of 95:5 heptane:toluene with a cooling rate of 5° C. per hour to provide 317.25 g of the titled compound as a white solid: 1H NMR (CDCl3) 7.12–6.85 (m, 10H), 5.90 (d, 1H, J=8.06 Hz), 5.72 (d, 1H, J=7.81), 3.83–3.76 (m, 1H), 1.95–1.89 (m, 1H), 1.35–1.31 (m, 1H). 1.11 (d, 3H, J=6.84), 1.10–0.95 (m, 3H), 0.92 (d, 3H, J=6.59), 0.76 (t, 3H, J=7.20) MS (APCl) M+1=366.2.

1. customA 22 L 4-neck round bottom flask was equipped with an addition funnel, mechanical stirrer, and nitrogen inlet
2. customThe system was purged with nitrogen for 1 hour
3. additionTHF (6 L) were charged to the flask
4. temperatureThe solution was cooled to −35° C.
5. customthe internal temperature of the reaction mixture below −25° C
6. stirringThe reaction was stirred for 1 hour
7. stirringthe reaction was stirred at −30° C. for 4 hours
8. waitThe reaction mixture was transferred over a 2 hour period into another 22 L flask
9. customequipped with a mechanical stirrer
10. stirringThe quenched solution was stirred for 30 minutes
11. stirringThe biphasic mixture was stirred for 15 minutes
12. customthe phases separated
13. washThe organic phase was washed 4× with 4 L aliquots of the 2M NH4OH solution
14. additionthe organic phase so the organic phase was diluted with 8 L of water
15. distillationthe THF was distilled off until the internal temperature of the distillation
16. custompot reached 95° C
17. temperatureThe suspension was cooled to ambient temperature
18. filtrationfiltered
19. washThe solids were washed with 4 L of water and suction
20. customdried
21. customto give 868.2 g of an off white solid
22. customThis material was recrystallized from 2 L of 95:5 heptane

ORD 기록

ord-abf78a87e959429a97aa22e034532acf

출처 데이터셋

uspto-grants-2007_02

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07179934B2