Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Codeine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Morphine | HCID 5288826 | — |
| 촉매 | Phenyltrimethylammonium chloride | HCID 67309 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Codeine | HCID 5284371 | 95.6% |
반응 단계
Morphine of 89.0% purity 320 parts (1 mole part), potassium carbonate 552 parts (4 moles part), water 65 parts and trimethylphenylammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene (4000 parts) at 45° to 120° C. for 2 to 8 hrs. to yield 296 parts codeine (95.6% yield after workup as in Example 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04764615 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-de6aa70261ab4783b10797d3fce05e0e |
| 출처 메모 | uspto-grants-1988_08 |