Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Codeine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Morphine | HCID 5288826 | — |
| 촉매 | Phenyltrimethylammonium chloride | HCID 67309 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Codeine | HCID 5284371 | 98% |
반응 단계
Morphine of 89% purity 320 parts (1 mole part), potassium carbonate 414 parts (3 moles part) and trimethylphenyl-ammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene (4000 parts) at 45°-110° C. for 3-8 hrs. to yield 293 parts of codeine (98.0% yield), after workup as in Example 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04764615 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-63cc52c60dae41f2b09880a3ea603c87 |
| 출처 메모 | uspto-grants-1988_08 |