Formic Acid → HCID 178470745, 화합물

HRID 349931노트

반응식

HRID 349931 반응식
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1[CH:7]=[N:8][N:9](CC2C=CC=CC=2)[C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH3:2].C(O)=O>[C].[Pd].C(O)C>[C:11]1([C:10]2[C:6]([CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:24])=[CH:7][NH:8][N:9]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

5

반응물 2

HCID 284Formic AcidHCID 70122986ethyl(1-benzyl-5-phenyl-1H-pyrazol-4-yl)acetate

생성물 1

HCID 178470745HCID 178470745, 화합물수율 90.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

A mixture of ethyl(1-benzyl-5-phenyl-1H-pyrazol-4-yl)acetate (3.60 g), 5% palladium-carbon (7.00 g), formic acid (40 ml), and ethanol (150 ml) was refluxed for 2 hours. After the palladium-carbon was removed by filtration, the filtrate was concentrated. The residue was dissolved in ethyl acetate, washed with saturated aqueous sodium bicarbonate and then with saturated aqueous sodium chloride solution, dried (MgSO4), and concentrated to obtain ethyl (3-phenyl-1H-pyrazol-4-yl)acetate (2.33 g, yield: 90%) as a colorless oily substance.

후처리

  1. temperaturewas refluxed for 2 hours
  2. customAfter the palladium-carbon was removed by filtration
  3. concentrationthe filtrate was concentrated
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. washwashed with saturated aqueous sodium bicarbonate
  6. dry with materialwith saturated aqueous sodium chloride solution, dried (MgSO4)
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6fdc3d33afd94580baedd7746148744e
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179823B1

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