Ethanol → HCID 178471163, 화합물

HRID 349942노트

반응식

HRID 349942 반응식
C([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:10]([O:20][CH2:21][CH3:22])=[N:9]1)C1C=CC=CC=1.C(O)C>[C].[Pd].C(O)=O>[CH2:21]([O:20][C:10]1[C:11]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:12][NH:8][N:9]=1)[CH3:22]

참가 물질

5

반응물 2

HCID 702EthanolHCID 23024912ethyl 3-(1-benzyl-3-ethoxy-1H-pyrazol-4-yl)propionate

생성물 1

HCID 178471163HCID 178471163, 화합물수율 72%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 284Formic Acid용매

실험 절차

A mixture of ethyl 3-(1-benzyl-3-ethoxy-1H-pyrazol-4-yl)propionate (21.20 g), 5% palladium-carbon (40.00 g), ethanol (200 ml), and formic acid (100 ml) was refluxed for one hour. After the palladium-carbon was removed by filtration, the filtrate was concentrated. The residue was dissolved in ethyl acetate, which was washed with saturated aqueous sodium bicarbonate and then with saturated aqueous sodium chloride solution, dried (MgSO4), and then concentrated. The residue was subjected to silica gel column chromatography, and ethyl 3-(3-ethoxy-1H-pyrazol-4-yl)propionate (10.70 g, yield: 72%) was obtained as a colorless oily substance from the fraction eluted with ethyl acetate-hexane (1:1, volume ratio).

후처리

  1. temperaturewas refluxed for one hour
  2. customAfter the palladium-carbon was removed by filtration
  3. concentrationthe filtrate was concentrated
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. washwhich was washed with saturated aqueous sodium bicarbonate
  6. dry with materialwith saturated aqueous sodium chloride solution, dried (MgSO4)
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4a04574051114ad59289ac9bdfa1a414
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179823B1

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