Oxalic acid dihydrate → N-(1-phenyl-3-pyrrolidinopropyl)quinaldinamide oxalate

HRID 35000

반응식

HRID 35000 반응식
[C:1]1([CH:7]([NH:15][C:16]([CH2:18][C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[N:20]=2)=[O:17])[CH2:8][CH2:9][N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.O.[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33]>C(O)C>[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33].[C:1]1([CH:7]([NH:15][C:16]([CH2:18][C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[N:20]=2)=[O:17])[CH2:8][CH2:9][N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 61373Oxalic acid dihydrateHCID 67930046N-(1-phenyl-3-pyrrolidinopropyl)quinaldinamide

생성물 1

HCID 67930065N-(1-phenyl-3-pyrrolidinopropyl)quinaldinamide oxalate수율 96%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In ethanol were dissolved 259 mg (0.72 mmol.) of N-(1-phenyl-3-pyrrolidinopropyl)quinaldinamide and 91 mg of oxalic acid dihydrate. The resulting solution was evaporated under reduced pressure to remove the solvent. The residue was recrystallized from a mixture of acetone (6 ml) and diethyl ether (3 ml) to obtain 310 mg (yield: 96%) of the subject compound as a white crystalline product.

후처리

  1. customThe resulting solution was evaporated under reduced pressure
  2. customto remove the solvent
  3. customThe residue was recrystallized from a mixture of acetone (6 ml) and diethyl ether (3 ml)

출처 및 근거

ORD 기록
ord-2aec0cad6b69427e995ed42842590707
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764617

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