Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 3-Piperidinopropiophenone hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Acetophenone | HCID 7410 | — |
| 반응물 | Piperidine, hydrochloride (1:1) | HCID 2723721 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-Piperidinopropiophenone hydrochloride | HCID 70171 | 75.4% |
반응 단계
A mixture of 120 g of acetophenone, 133 g of piperidine hydrochloride and 50 g of paraformaldehyde in 120 ml of ethanol was refluxed for 6 hours. The mixture was then allowed to stand for cooling to soldify. The resulting solid was crushed after addition of 400 ml of acetone, and then collected by filtration. The collected solid was washed successively with acetone and hexane and dried to obtain 191.6 g (yield: 75.4%) of the subject compound as a white scaly product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04764617 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-2a8bdce2894f4e98a5de81fcefcaeafc |
| 출처 메모 | uspto-grants-1988_08 |