Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-[3-[4-[2-(Dimethylamino)ethyl]phenoxy]propyl]-1H-isoindole-1,3-(2H)-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | N-3-Bromopropylphthalimide | HCID 21611 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Hordenine | HCID 68313 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-[3-[4-[2-(Dimethylamino)ethyl]phenoxy]propyl]-1H-isoindole-1,3-(2H)-dione | HCID 21297567 | — |
반응 단계
A mixture of 4-[2-(dimethylamino)ethyl]phenol (4.13 g) and sodium hydride (0.67 g) in dimethylformamide was stirred at room temperature for 24 h. N-(3-Bromopropyl)phthalimide (6.7 g) was added at 0° and stirring was continued for 24 h. The solution was treated with water and extracted with ether. Evaporation of the solvent gave the title compound as a white solid which was recrystallised from light petroleum (b.p. 60°-80°) 2.3 g) m.p. 81°-82°. TLC silica; ethyl acetate:water:isopropanol:0.88 ammonia 25:8:15:2; Rf 0.45.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04764612 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-f61d192139224915935bb2181c5c3082 |
| 출처 메모 | uspto-grants-1988_08 |