Acetic Acid → HCID 23061948, 화합물
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[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=O)[CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.[C-]#[N:13].[K+].C[CH:16]([OH:18])C.C(O)(=O)C>O>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:13][C:16](=[O:18])[O:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1참가 물질
6
실험 절차
To a mixed solution of 1-(3-chlorophenyl)-2-hydroxyethanone (21.8 g), potassium cyanide (20.8 g) and 2-propanol (100 mL) was added acetic acid (18 mL) at room temperature. After stirring for 30 min, water was added, and the precipitated crystals were collected by filtration and recrystallized from methanol-diisopropyl ether to give 4-(3-chlorophenyl)oxazol-2(3H)-one (6.7 g, yield 41%) as a solid.
후처리
- filtrationthe precipitated crystals were collected by filtration
- customrecrystallized from methanol-diisopropyl ether
출처 및 근거
- ORD 기록
- ord-a9e8cc26de6e4b78b32beb6c7e737c38
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07183276B2
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