1-(4-Nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione → 1-(4-Aminophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione

HRID 35078

반응식

HRID 35078 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]23[CH2:16][CH:14]([CH2:15]2)[C:13](=[O:17])[NH:12][C:11]3=[O:18])=[CH:6][CH:5]=1)([O-])=O>COCCO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]23[CH2:15][CH:14]([CH2:16]2)[C:13](=[O:17])[NH:12][C:11]3=[O:18])=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 148726291-(4-Nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione

생성물 1

HCID 148726341-(4-Aminophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 80192-Methoxyethanol용매

실험 절차

In a manner analogous to that described in Example 1a, 5.0 g of 1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione in 250 ml of 2-methoxyethanol are hydrogenated at 45° in the presence of 0.5 g of 5% palladium-on-carbon and worked up. The title compound is obtained which, after recrystallisation from 2-methoxyethanol, melts at 265° with decomposition.

출처 및 근거

ORD 기록
ord-ba979a78f059435198692ae5c9f14039
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764640

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