3-Benzyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione → 1-(4-Aminophenyl)-3-benzyl-3-azabicyclo[3.1.1]heptane-2,4-dione

HRID 35079

반응식

HRID 35079 반응식
[CH2:1]([N:8]1[C:13](=[O:14])[CH:12]2[CH2:15][C:10]([C:16]3[CH:21]=[CH:20][C:19]([N+:22]([O-])=O)=[CH:18][CH:17]=3)([CH2:11]2)[C:9]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CCOCC.C(OCC)(=O)C>C(OCC)(=O)C.[Pd]>[NH2:22][C:19]1[CH:20]=[CH:21][C:16]([C:10]23[CH2:15][CH:12]([CH2:11]2)[C:13](=[O:14])[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:9]3=[O:25])=[CH:17][CH:18]=1

참가 물질

5

반응물 2

HCID 148726333-Benzyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dioneHCID 21584169Diethylether ethylacetate

생성물 1

HCID 148726381-(4-Aminophenyl)-3-benzyl-3-azabicyclo[3.1.1]heptane-2,4-dione

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

In a manner analogous to that described in Example 1a, 2.46 g of 3-benzyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione are dissolved in 50 ml of ethyl acetate, hydrogenated in the presence of 0.3 g of 5% palladium-on-carbon and worked up. Melting point 164°-165.5° (from ether/ethyl acetate).

출처 및 근거

ORD 기록
ord-c9d1fe1a90394c208267d55bc38fcf9f
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764640

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