Potassium Carbonate → 4-((Isopropyl(methyl)amino)methyl)thiazol-2-amine

HRID 350957

반응식

HRID 350957 반응식
[CH3:1][NH:2][CH:3]([CH3:5])[CH3:4].Cl.[NH2:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13]Cl)[N:12]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH:3]([N:2]([CH2:13][C:11]1[N:12]=[C:8]([NH2:7])[S:9][CH:10]=1)[CH3:1])([CH3:5])[CH3:4]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 732282-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1)HCID 78485N-Methylisopropylamine

생성물 1

HCID 210906044-((Isopropyl(methyl)amino)methyl)thiazol-2-amine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

N-methyl-N-isopropylamine (3.02 g, 41 mmol) is added to a suspension of 2-amino-4-chloromethylthiazole hydrochloride (0.185 g, 1.0 mmol) in 15 mL ethanol. The reaction mixture is allowed to stand at room temperature for 4 days. The mixture was poured into aqueous potassium carbonate. The resulting aqueous suspension is extracted with dichloromethane. The organic layer is dried over MgSO4 and condensed to brown oil.

후처리

  1. extractionThe resulting aqueous suspension is extracted with dichloromethane
  2. dry with materialThe organic layer is dried over MgSO4 and condensed to brown oil

출처 및 근거

ORD 기록
ord-c3743e0ec4dd42899e707ab5c78cd1e5
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183300B2

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