(4-Cyano-3-fluoro-phenoxy)-acetic acid methyl ester → Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetate

HRID 350979

반응식

HRID 350979 반응식
[CH3:1][O:2][C:3](=[O:15])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[C:8]([F:14])[CH:7]=1.C(OC(=O)C(OC1C=CC(C#N)=C(F)C=1)C)(C)(C)C>>[CH3:1][O:2][C:3](=[O:15])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH2:13])=[C:8]([F:14])[CH:7]=1

참가 물질

3

반응물 2

HCID 23529353(4-Cyano-3-fluoro-phenoxy)-acetic acid methyl esterHCID 235293652-(4-Cyano-3-fluoro-phenoxy)-propionic acid tert-butyl ester

생성물 1

HCID 18174008Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetate

실험 절차

The compound of Formula (5.0.19) was prepared in a manner analogous to that described in Preparation 10, substituting (4-cyano-3-fluoro-phenoxy)-acetic acid methyl ester for the corresponding 2-(4-cyano-3-fluoro-phenoxy)-propionic acid tert-butyl ester material.

후처리

  1. customthat described in Preparation 10

출처 및 근거

ORD 기록
ord-449755305d3f41b08bd8bc95d22deba1
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183293B2

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