2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid → (+)-2-[3-Fluoro-4-({[2-(3-cyano-phenoxy)-pyridine-3-carbonyl]-amino}-methyl)-phenoxy]-propionic acid tert-butyl ester

HRID 350983

반응식

HRID 350983 반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[O:6][C:7]1[N:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=O)#[N:2].[C:19]([O:23][C:24](=[O:37])[CH:25]([O:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][NH2:35])=[C:30]([F:36])[CH:29]=1)[CH3:26])([CH3:22])([CH3:21])[CH3:20].O1C2C=CC(OC3N=CC=CC=3C(O)=O)=CC=2OC1.COC(=O)COC1C=CC(CN)=C(F)C=1>>[C:19]([O:23][C:24](=[O:37])[CH:25]([O:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][NH:35][C:9]([C:8]2[C:7]([O:6][C:5]3[CH:16]=[CH:17][CH:18]=[C:3]([C:1]#[N:2])[CH:4]=3)=[N:15][CH:14]=[CH:13][CH:12]=2)=[O:11])=[C:30]([F:36])[CH:29]=1)[CH3:26])([CH3:20])([CH3:21])[CH3:22]

참가 물질

5

반응물 4

HCID 27368792-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acidHCID 128493352-(3-Cyano-phenoxy)-nicotinic acidHCID 18174008Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetateHCID 23529364(+)-2-(4-Aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester

생성물 1

HCID 23529361(+)-2-[3-Fluoro-4-({[2-(3-cyano-phenoxy)-pyridine-3-carbonyl]-amino}-methyl)-phenoxy]-propionic acid tert-butyl ester

실험 절차

The compound of Formula (5.0.25) was prepared in a manner analogous to that described in Preparation 20, substituting 2-(3-cyano-phenoxy)-nicotinic acid and (+)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester for the corresponding 2-(benzo-[1,3]-dioxol-5-yloxy)-nicotinic acid and (4-aminomethyl-3-fluoro-phenoxy)-acetic acid methyl ester materials, respectively.

후처리

  1. customthat described in Preparation 20

출처 및 근거

ORD 기록
ord-14d58f1b611349469fbd5b246243a589
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183293B2

연결된 노트

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