Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid → (+)-2-[4-({[2-(Benzo[2,1,3]thiadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid | HCID 2736879 | — |
| 반응물 | Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetate | HCID 18174008 | — |
| 반응물 | 2-(Benzo[2,1,3]thiadiazol-5-yloxy)-nicotinic acid | HCID 22610159 | — |
| 반응물 | (+)-2-(4-Aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester | HCID 23529364 | — |
| 생성물 | (+)-2-[4-({[2-(Benzo[2,1,3]thiadiazol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid tert-butyl ester | HCID 23529360 | — |
반응 단계
The compound of Formula (5.0.27) was prepared in a manner analogous to that described in Preparation 20, substituting 2-(benzo[2,1,3]thiadiazol-5-yloxy)-nicotinic acid and (+)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester for the corresponding 2-(benzo-[1,3]-dioxol-5-yloxy)-nicotinic acid and (4-aminomethyl-3-fluoro-phenoxy)-acetic acid methyl ester materials, respectively.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07183293B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-1aab8af1c7a04bd29b59d1e2942d1556 |
| 출처 메모 | uspto-grants-2007_02 |