Dichloromethane → 3-[3-(Naphthalen-1-ylsulfamoyl)phenyl]-acryloyl Chloride

HRID 351059노트

반응식

HRID 351059 반응식
[C:1]1([NH:11][S:12]([C:15]2[CH:16]=[C:17]([CH:21]=[CH:22][C:23]([OH:25])=O)[CH:18]=[CH:19][CH:20]=2)(=[O:14])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Cl:26]CCl>CN(C)C=O>[C:1]1([NH:11][S:12]([C:15]2[CH:16]=[C:17]([CH:21]=[CH:22][C:23]([Cl:26])=[O:25])[CH:18]=[CH:19][CH:20]=2)(=[O:14])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 6344DichloromethaneHCID 670195673-[3-(Naphthalen-1-ylsulfamoyl)-phenyl]-acrylic acid

생성물 1

HCID 739894023-[3-(Naphthalen-1-ylsulfamoyl)phenyl]-acryloyl Chloride수율 99.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

반응 조건

온도
40 °C

실험 절차

To a suspension of 3-[3-(naphthalen-1-ylsulfamoyl)-phenyl]-acrylic acid (15d) (0.22 g, 0.62 mmol) in dichloromethane (2.5 ml) oxalyl chloride (0.16 ml, 1.86 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.23 g, 99%).

후처리

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-eb5776f0e77a4c51a1705fb109988248
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183298B2

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