Benzodiazepine → 9-Methylthio-6-(4-methyl-1-piperazinyl)1,2-dihydrobenzo[b]pyrrolo(3,2,1-jk][1,4]benzodiazepine

HRID 35108

반응식

HRID 35108 반응식
[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([N:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:21][CH2:20]2)=[C:7]([NH:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)=O)[CH:8]=1.N1C2C=CC=CC=2C=CC=N1>>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]2[N:19]3[CH2:20][CH2:21][C:22]4[C:27]3=[C:26]([CH:25]=[CH:24][CH:23]=4)[C:10]([N:12]3[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]3)=[N:9][C:7]=2[CH:8]=1

참가 물질

3

반응물 2

HCID 134664BenzodiazepineHCID 21297642N-[5-methylthio-2-(2,3-dihydro-1H-indol-1-yl)phenyl]-4-methyl-1-piperazinecarboxamide

생성물 1

HCID 212976439-Methylthio-6-(4-methyl-1-piperazinyl)1,2-dihydrobenzo[b]pyrrolo(3,2,1-jk][1,4]benzodiazepine

실험 절차

It is predicted that if the N-[5-methylthio-2-(2,3-dihydro-1H-indol-1-yl)phenyl]-4-methyl-1-piperazinecarboxamide of Example 10c is treated in the manner of Example 4c that 9-methylthio-6-(4-methyl-1-piperazinyl)1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk]-1,4]benzodiazepine will be obtained.

후처리

  1. customwill be obtained

출처 및 근거

ORD 기록
ord-1a281a895d2f412a864856c6cfa364a7
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764616

연결된 노트

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