Diethyl Ether → HCID 10084623, 화합물

HRID 351110노트

반응식

HRID 351110 반응식
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][C:6]1[S:10][C:9]2[C:11]3[C:16]([CH2:17][C:8]=2[C:7]=1[C:18]([NH2:20])=[O:19])=[CH:15][CH:14]=[CH:13][CH:12]=3.C(OCC)C>N1C=CC=CC=1>[C:1]([NH:5][C:6]1[S:10][C:9]2[C:11]3[C:16]([CH2:17][C:8]=2[C:7]=1[C:18]([NH2:20])=[O:19])=[CH:15][CH:14]=[CH:13][CH:12]=3)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 6367Acetyl chlorideHCID 10220223HCID 10220223, 화합물

생성물 1

HCID 10084623HCID 10084623, 화합물수율 87%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Acetyl chloride (0.039 g, 0.5 mmol) was added dropwise to a stirred solution of 2-amino-4H-indeno[1,2-b]thiophene-3-carboxylic acid amide(0.115 g, 0.5 mmol) in dry pyridine (3 mL) at room temperature. The resulting reaction mixture was stirred under nitrogen for 2 h. Ethyl ether (20 mL) was then added to the reaction mixture. The reaction mixture was allowed to stir an additional 10 minutes. The reaction mixture was then filtered, washed with excess ethyl ether, air dried to give the title compound as light brown solid (0.082 g, 0.435 mmol, 60.3% yield). ESMS m/z: 273 [M+H]+.

후처리

  1. customThe resulting reaction mixture
  2. stirringto stir an additional 10 minutes
  3. filtrationThe reaction mixture was then filtered
  4. washwashed with excess ethyl ether, air
  5. customdried

출처 및 근거

ORD 기록
ord-73fe2dbbfcfe48d5b116748357374bf3
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183311B2

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