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2,5-Dimethoxytetrahydrofuran → 2-{4-[1-[4-(1H-pyrrol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenyl}ethyl acetate

HRID 351260
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HRID 351260 반응식
[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=3)[N:16]=[C:15]([C:25]([F:28])([F:27])[F:26])[CH:14]=2)=[CH:9][CH:8]=1)(=[O:3])[CH3:2].CO[CH:31]1[CH2:35][CH2:34][CH:33](OC)O1>CC(O)=O>[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][C:21]([N:24]4[CH:31]=[CH:35][CH:34]=[CH:33]4)=[CH:20][CH:19]=3)[N:16]=[C:15]([C:25]([F:26])([F:28])[F:27])[CH:14]=2)=[CH:11][CH:12]=1)(=[O:3])[CH3:2]
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참가 물질

4

반응물 2

HCID 790982,5-Dimethoxytetrahydrofuran2회HCID 210907062-{4-[1-(4-aminophenyl)-3-(trifluoro-methyl)-1H-pyrazol-5-yl]phenyl}ethyl acetate

생성물 1

HCID 210907052-{4-[1-[4-(1H-pyrrol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenyl}ethyl acetate수율 72.8%

시약·촉매·용매 1

HCID 176Acetic Acid용매

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온도
50 °C

실험 절차

A mixture of 2-{4-[1-(4-aminophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenyl}ethyl acetate 165.6 mg and 2,5-dimethoxytetrahydrofuran 112 mg in AcOH 3 ml was stirred at 50° C. for 3 hours. 2,5-Dimethoxytetrahydrofuran 0.22 ml was added and the mixture was stirred at 50° C. for 2 hours. The mixture was partitioned between ethyl acetate and H2O. The organic layer was washed with saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo. The residue was purified by preparative thin layer silica gel chromatography developed by AcOEt/n-hexane=20%. The separated silica gel was extracted with 10% MeOH/CHCl3 and the solvent was evaporated in vacuo to give 2-{4-[1-[4-(1H-pyrrol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenyl}ethyl acetate 136.1 mg as an oil.

후처리

  1. stirringthe mixture was stirred at 50° C. for 2 hours
  2. customThe mixture was partitioned between ethyl acetate and H2O
  3. washThe organic layer was washed with saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified by preparative thin layer silica gel chromatography
  7. extractionThe separated silica gel was extracted with 10% MeOH/CHCl3
  8. customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-fee74556b62b4488bade5b3d017dce4f
출처 데이터셋
uspto-grants-2007_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07183306B2

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