2,2,2-Trifluoroacetophenone → N-(2,2,2-Trifluoro-1-phenylethylidene)-L-valine potassium salt

참여 물질

역할	이름	HCID	투입량
반응물	2,2,2-Trifluoroacetophenone	HCID 9905	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	l-Valine, ethyl ester	HCID 87182	—
용매	Methanol	HCID 887	—
생성물	N-(2,2,2-Trifluoro-1-phenylethylidene)-L-valine potassium salt	HCID 58599713	—

반응 조건

온도	50 °C

반응 단계

2,2,2-Trifluoroacetophenone (4.24 g, 24.3 mmol) was added to a mixture of L-valine ethyl ester (3.21 g, 22.1 mmol) and K2CO3 (2.90 g, 20.9 mmol) in MeOH (50 mL). The mixture was warmed to 50° C. for 18 h. The mixture was cooled to 20–25° C., filtered and concentrated. The residue was suspended in TBME (100 ml) and filtered to give the title compound as a white solid.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07183425B2
출처 데이터셋	uspto-grants-2007_02
ORD ID	ord-9b16be21d1324a09bd32db5352ab2673
출처 메모	uspto-grants-2007_02