Ethanol → HCID 23022412, 화합물

HRID 351347

반응식

HRID 351347 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][F:6].[F:7][C:8]1[CH:16]=[C:15]([OH:17])[CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=[O:11].C(O)C.[OH-].[K+]>O>[F:7][C:8]1[CH:16]=[C:15]([O:17][CH2:2][CH2:3][CH2:4][CH2:5][F:6])[CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=[O:11]

참가 물질

6

반응물 4

HCID 702EthanolHCID 100221-Bromo-4-fluorobutaneHCID 14797Potassium HydroxideHCID 27833982-Fluoro-4-hydroxybenzoic Acid

생성물 1

HCID 23022412HCID 23022412, 화합물수율 39.1%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

1-Bromo-4-fluorobutane (3.57 g, 23.1 mmol) was added dropwise to a mixture of 2-fluoro-4-hydroxybenzoic acid (3.00 g, 19.2 mmol), ethanol (11.5 ml) and water (2.3 ml), potassium hydroxide (2.37 g, 42.3 mmol) at 80° C., and the mixture was stirred at 80° C. for 17 hrs. The solvent was evaporated under reduced pressure. The residue was dissolved in water and the solution was acidified by adding 1N hydrochloric acid. The insoluble materials were filtered off and dried to give the title compound (1.73 g) as a pale-brown powder.

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. additionby adding 1N hydrochloric acid
  4. filtrationThe insoluble materials were filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-a90d447d5d524a98a661fb371990aede
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183415B2

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