Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetamidomalonic acid diethyl ester → Diethyl 2-acetamido-2-(diphenylmethyl)malonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetamidomalonic acid diethyl ester | HCID 14041 | — |
| 반응물 | Bromodiphenylmethane | HCID 236603 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Diethyl 2-acetamido-2-(diphenylmethyl)malonate | HCID 14211495 | — |
반응 단계
Dissolve sodium (2 g) in 400 ml ethanol and add diethyl acetamidomalonate (10.4 g). Stir 5 minutes, add diphenyl bromomethane (12.4 g), and stir 7 hours at room temperature. Acidify the reaction mixture, partition between water and methylene chloride (CH2Cl2), dry the organic layer over magnesium sulfate (MgSO4), filter, and evaporate the solvent to obtain the crude title compound as a pale yellow oil. Rf (silica gel; Et2O)=0.89.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04766109 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-18b2b873df424d9bacf447d4ae203cba |
| 출처 메모 | uspto-grants-1988_08 |