참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 1-Bromohexane | HCID 8101 | — |
| 반응물 | Potassium Bicarbonate | HCID 516893 | — |
| 반응물 | 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone | HCID 712441 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-Acetyl-4-(4-hexyloxyphenyl)piperazine | HCID 22713243 | — |
반응 단계
To a suspension of 1-acetyl-4-(4-hydroxyphenyl) piperazine (20 g) and potassium bicarbonate (12.55 g) in dimethylsulfoxide (200 ml) was added 1-bromohexane (19.12 ml) and stirred for 24 hours at 80° C. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken and dried over is magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-acetyl-4-(4-hexyloxyphenyl)piperazine (14.5 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06743776B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_06 |
|---|
| ORD ID | ord-55960f6b25f8486b9db79f648a9dc4ae |
|---|
| 출처 메모 | uspto-grants-2004_06 |
|---|
