1,4-Dioxa-8-azaspiro(4.5)decane → HCID 22713327, 화합물

반응식

[O:1]1[C:5]2([CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.F[C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][CH2:23][OH:24])(=[O:20])=[O:19])=[CH:14][CH:13]=1>>[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C:12]3[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][CH2:23][OH:24])(=[O:20])=[O:19])=[CH:14][CH:13]=3)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 674351,4-Dioxa-8-azaspiro(4.5)decane

HCID 15876834-Fluoro-N-(2-hydroxyethyl)benzenesulfonamide

생성물 1

HCID 22713327HCID 22713327, 화합물

실험 절차

The title compound was prepared according to the procedure of Intermediate 24 from 2.28 g (15.6 mmol) of 1,4-dioxa-8-aza-spiro[4.5]decane and 2.85 g (13.0 mmol) of 4-fluoro-N-(2-hydroxyethyl)-benzenesulfonamide, yielding 3.0 g of a colorless gum; MS (ES) m/z 343.2 (MH+); HRMS (EI) Calcd. for C15H22N2O5S (M+): 342.1249, Found: 342.1235.

출처 및 근거

ORD 기록: ord-5421c2fe343743d9956797a2fb3160fc
출처 데이터셋: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06743787B2

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