Dimethyl-p-toluidine → 2-Chloro-4-(2,4-dimethoxy-benzyl)-7-methyl-3,4-dihydro-benzo[e][1,4]diazepin-5-one

참여 물질

역할	이름	HCID	투입량
반응물	Dimethyl-p-toluidine	HCID 7471	—
반응물	Phosphorus oxychloride	HCID 24813	—
반응물	4-(2,4-Dimethoxy-benzyl)-7-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione	HCID 22713527	—
용매	Toluene	HCID 1140	—
생성물	2-Chloro-4-(2,4-dimethoxy-benzyl)-7-methyl-3,4-dihydro-benzo[e][1,4]diazepin-5-one	HCID 22713471	—

반응 조건

온도	100 °C

반응 단계

4-(2,4-Dimethoxy-benzyl)-7-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (34.0 g, 100 mmol) and N,N-dimethyl-p-toluidine (28.9 mL, 200 mmol) were mixed in toluene (100 mL) and heated to 100° C. Then phosphorus oxychloride (10.1 mL, 110 mmol) was added dropwise and heating at 100° C. was continued for 2.5 h. The resulting dark red solution was used directly in the subsequent step.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06743789B2
출처 데이터셋	uspto-grants-2004_06
ORD ID	ord-6064c7e3293a48e999426f7cafe2ad4c
출처 메모	uspto-grants-2004_06