Potassium Carbonate → HCID 22714487, 화합물

HRID 351929

반응식

HRID 351929 반응식
[C:1]1([CH:7]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([OH:23])=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:25][CH2:26][CH2:27][CH2:28][OH:29].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:1]1([CH:7]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([O:23][CH2:25][CH2:26][CH2:27][CH2:28][OH:29])=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 1183884-BromobutanolHCID 15549281Ethyl 3-phenyl-3-(6-hydroxyindol-3-yl)propionate

생성물 1

HCID 22714487HCID 22714487, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Analogously to Example 1.4, 1.2 g (3.88 mmol) of ethyl 3-phenyl-3-(6-hydroxyindol-3-yl)propionate are reacted with 1.16 g (7.6 mmol) of 4-bromo-1-butanol in the presence of 2.1 g (15.2 mmol) of potassium carbonate in 30 ml of acetone, giving ethyl 3-phenyl-3-[6-(4-hydroxybutoxy)indol-3-yl]propionate.

출처 및 근거

ORD 기록
ord-bdbe467bff3347989743f13f1d11a32d
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743810B2

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