Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Ethyl 3-phenyl-3-[6-(tert-butoxycarbonylmethoxy)indol-3-yl]propionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | tert-Butyl bromoacetate | HCID 79177 | — |
| 반응물 | Ethyl 3-phenyl-3-(6-hydroxyindol-3-yl)propionate | HCID 15549281 | — |
| 반응물 | Toluene acetone | HCID 20247278 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Ethyl 3-phenyl-3-[6-(tert-butoxycarbonylmethoxy)indol-3-yl]propionate | HCID 22714448 | — |
반응 단계
The compound ethyl 3-phenyl-3-(6-hydroxyindol-3-yl)propionate 4 prepared analogously to Example 1.1-1.3 (3.23 mmol) is stirred overnight at 60° C. with 0.94 ml (6.4 mmol) of tert-butyl bromoacetate and 1.8 g (13 mmol) of potassium carbonate in 20 ml of acetone. When the reaction is complete (TLC check toluene/acetone 4:1), the residue is filtered off, the solution is evaporated, and the crude product is purified by chromatography on silica gel (eluent toluene/acetone 9:1), giving ethyl 3-phenyl-3-[6-(tert-butoxycarbonylmethoxy)indol-3-yl]propionate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06743810B2 |
| 출처 데이터셋 | uspto-grants-2004_06 |
| ORD ID | ord-aedfb14ae3144d6d8767b8e89bac1c8d |
| 출처 메모 | uspto-grants-2004_06 |