Triethylamine → HCID 22714422, 화합물

HRID 351933노트

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HRID 351933 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[CH:8][CH:7]=1.Br.CC1C([C:22]2[NH:23][CH2:24][CH2:25][N:26]=2)=C(C)NN=1.C(N(CC)CC)C>CN(C=O)C>[NH:26]1[CH2:25][CH2:24][N:23]=[C:22]1[NH:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 22714433HCID 22714433, 화합물HCID 534351342-(3,5-Dimethylpyrazolyl)-4,5-dihydroimidazole hydrobromide

생성물 1

HCID 22714422HCID 22714422, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
60 °C

실험 절차

500 mg (2.6 mmol) of 6-(3-aminopropoxy)indole 23 [prepared in accordance with Example 9.1] are dissolved in 10 ml of DMF together with 0.97 g (3.9 mmol) of 2-(3,5-dimethylpyrazolyl)-4,5-dihydroimidazole hydrobromide and 1.7 ml (11.9 mmol) of triethylamine, and the solution is stirred at 60° C. for 12 hours. After the solution has been evaporated, the crude product is purified by preparative HPLC.

후처리

  1. customAfter the solution has been evaporated
  2. customthe crude product is purified by preparative HPLC

출처 및 근거

ORD 기록
ord-4e580d69350a4fb78f11816bd2b49ae8
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743810B2

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