Sodium Iodide → 4-Chloro-2-[[(1r)-4-iodo-1-phenylbutyl]oxy]benzonitrile

HRID 352104노트

반응식

HRID 352104 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:10][C@@H:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:12][CH2:13][CH2:14]Cl)[CH:3]=1.[I-:22].[Na+]>CC(C)=O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:10][C@@H:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:12][CH2:13][CH2:14][I:22])[CH:3]=1

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 698293454-Chloro-2-[[(1r)-4-chloro-1-phenylbutyl]oxy]benzonitrile

생성물 1

HCID 698282664-Chloro-2-[[(1r)-4-iodo-1-phenylbutyl]oxy]benzonitrile수율 89.5%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of the product from step (b) (2.80 g) and sodium iodide (20 g) in acetone (100 ml) was heated under reflux for 20 h. The mixture was filtered, evaporated, dissolved in water (50 ml) and extracted with ethyl acetate (three times). The organic extracts were washed with water, dried (magnesium sulphate) and evaporated to give the title compound (3.22 g).

후처리

  1. temperatureunder reflux for 20 h
  2. filtrationThe mixture was filtered
  3. customevaporated
  4. dissolutiondissolved in water (50 ml)
  5. extractionextracted with ethyl acetate (three times)
  6. washThe organic extracts were washed with water
  7. dry with materialdried (magnesium sulphate)
  8. customevaporated

출처 및 근거

ORD 기록
ord-7a27ffd422234668b1774412e87fb8de
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743939B2

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