Sodium Iodide → 2-[1-(2,5-Dichlorophenoxy)-4-iodobutyl]thiophene

HRID 352110노트

반응식

HRID 352110 반응식
Cl[CH2:2][CH2:3][CH2:4][CH:5]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)[O:6][C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:8]=1[Cl:14].[I-:20].[Na+]>CC(C)=O>[Cl:14][C:8]1[CH:9]=[CH:10][C:11]([Cl:13])=[CH:12][C:7]=1[O:6][CH:5]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)[CH2:4][CH2:3][CH2:2][I:20]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 227151352-[4-Chloro-1-(2,5-dichlorophenoxy)butyl]thiophene

생성물 1

HCID 227151002-[1-(2,5-Dichlorophenoxy)-4-iodobutyl]thiophene수율 95%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

2-[4-Chloro-1-(2,5-dichlorophenoxy)butyl]thiophene (2.4 g, 7.1 mmol) was dissolved in a saturated solution of sodium iodide in acetone (200 ml) and the reaction refluxed for 20 hours. The reaction mixture was cooled and the solid filtered off. The filtrate was evaporated in vacuo and the residue taken up in water (50 ml). The mixture was extracted with diethyl ether (3×70 ml) and the combined organic portions were washed with water (3×30 ml), dried (magnesium sulphate), filtered and evaporated in vacuo to give the title compound as a pale straw coloured oil (2.91 g, 95%).

후처리

  1. temperaturethe reaction refluxed for 20 hours
  2. temperatureThe reaction mixture was cooled
  3. filtrationthe solid filtered off
  4. customThe filtrate was evaporated in vacuo
  5. extractionThe mixture was extracted with diethyl ether (3×70 ml)
  6. washthe combined organic portions were washed with water (3×30 ml)
  7. dry with materialdried (magnesium sulphate)
  8. filtrationfiltered
  9. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-69960454100b48cfb073fa3355c7f2ef
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743939B2

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