B.CB1N2CCC[C@@H]2C(C2C=CC=CC=2)(C2C=CC=CC=2)O1.[CH3:23][C:24]([O:27][C:28](=[O:43])[NH:29][CH2:30][CH2:31][CH2:32][C:33]([C:35]1[C:36]([O:41][CH3:42])=[N:37][CH:38]=[CH:39][CH:40]=1)=[O:34])([CH3:26])[CH3:25].CO>O1CCCC1>[CH3:26][C:24]([O:27][C:28](=[O:43])[NH:29][CH2:30][CH2:31][CH2:32][CH:33]([OH:34])[C:35]1[C:36]([O:41][CH3:42])=[N:37][CH:38]=[CH:39][CH:40]=1)([CH3:23])[CH3:25]Borane (0.7 ml, 1M in tetrahydrofuran) was added to a solution of (3aR)-tetrahydro-1-methyl-3,3-diphenyl-3H-pyrrolo[1,2-c][1,3,2]oxazaborole (0.05 ml, 1M in toluene) in tetrahydrofuran (2 ml) at 0° C. A solution of the product from step (a) above (0.304 g) in tetrahydrofuran (3 ml) was added over 20 minutes and then stirred at 0° C. for 4hand at 20° C. for 14 h. Methanol was added and the solution was evaporated and the residue azeotroped with methanol. Purification by chromatography on silica eluting with petrol-ether gave the sub-title compound as a colourless oil (0.255 g).
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