Sodium Bicarbonate → 5-(3-Amino-cyclohexyl)-9-chloro-3-methyl-5H-isoxazolo[4,3-c]quinolin-4-one

HRID 352237노트

반응식

HRID 352237 반응식
I.[NH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH:5]([N:9]2[C:18]3[CH:17]=[CH:16][CH:15]=[C:14]([Cl:19])[C:13]=3[C:12]3=[N:20][O:21][C:22]([CH3:23])=[C:11]3[C:10]2=[O:24])[CH2:4]1.C([O-])(O)=O.[Na+]>>[NH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH:5]([N:9]2[C:18]3[CH:17]=[CH:16][CH:15]=[C:14]([Cl:19])[C:13]=3[C:12]3=[N:20][O:21][C:22]([CH3:23])=[C:11]3[C:10]2=[O:24])[CH2:4]1

참가 물질

3

반응물 2

HCID 516892Sodium BicarbonateHCID 227137135-(3-Aminocyclohexyl)-9-chloro-3-methyl-5H-isoxazolo[4,3-c]quinolin-4-one hydroiodide

생성물 1

HCID 227137145-(3-Amino-cyclohexyl)-9-chloro-3-methyl-5H-isoxazolo[4,3-c]quinolin-4-one수율 98%

실험 절차

A compound from Example 634 (350 mg,0.95 mmol) was treated with excess aqueous NaHCO3 and the mixture extracted with EtOAc. The combined extracts were dried over Na2SO4 and concentrated in vacuo to yield 309 mg (98%) of the title compound.

후처리

  1. extractionthe mixture extracted with EtOAc
  2. dry with materialThe combined extracts were dried over Na2SO4
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-f1f4016b20b04d1a86714a40492d5889
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743794B2

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