Triethylamine → HCID 131724455, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide	HCID 15908	—
반응물	3,4,5-Trimethoxyphenylacetic acid	HCID 70372	—
반응물	1-Hydroxybenzotriazole	HCID 75771	—
반응물	HCID 22713955	HCID 22713955	—
촉매	4-(Dimethylamino)pyridine	HCID 14284	—
용매	Dichloromethane	HCID 6344	—
생성물	HCID 131724455	HCID 131724455	66%

반응 단계

To a stirred solution of racemic 5-(3-aminocyclopentyl)-9-chloro-3-methyl-5H-isoxazolo[4,3-c]quinolin-4-one (81 mg, 0.26 mmol) in CH2Cl2 (3 mL) was added 3,4,5-trimethoxy phenyl acetic acid (114 mg, 0.52 mmol), Et3N (0.1 mL, 0.50 mmol), HOBt (41 mg, 0.3 mmol),DMAP (catalytic amount) and EDCI (72 mg, 0.38 mmol). The reaction mixture was stirred at r.t. for 18 hours. The mixture was diluted with CH2Cl2, washed (brine), dried (Na2SO4), filtered and concentrated. Column chromatography (silica gel, hexanes/ethyl acetate, gradient) gave the racemic title compound (89 mg, 66%). Mass Spectrum (FIA) (m/z) 454.0 (M+1)

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06743794B2
출처 데이터셋	uspto-grants-2004_06
ORD ID	ord-3f64bbca03c94c9d838d6d8d06135089
출처 메모	uspto-grants-2004_06