Thionyl Chloride → 2-(Chloromethyl)naphthalene

HRID 352343

반응식

HRID 352343 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11]O.S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1.ClCCl>[Cl:15][CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 741282-Naphthalenemethanol

생성물 1

HCID 756322-(Chloromethyl)naphthalene

시약·촉매·용매 2

HCID 1140Toluene용매HCID 6344Dichloromethane용매

실험 절차

To 1.26 mol of naphth-2-yl-methanol in 1.5 liters of toluene there are slowly added 3.8 mol of thionyl chloride. The mixture is then heated at reflux for two hours. After cooling, the solvent is evaporated off. The crude product is taken up in toluene twice and evaporated. The oil obtained is taken up in dichloromethane, washed and dried. After filtering and evaporating, the oil obtained is distilled to yield the expected product.

후처리

  1. temperatureThe mixture is then heated
  2. temperatureat reflux for two hours
  3. temperatureAfter cooling
  4. customthe solvent is evaporated off
  5. customevaporated
  6. customThe oil obtained
  7. washwashed
  8. customdried
  9. filtrationAfter filtering
  10. customevaporating
  11. customthe oil obtained
  12. distillationis distilled

출처 및 근거

ORD 기록
ord-2b76a36fe9d8421e9983fe191e681c45
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06747032B2

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