Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 1-Acetyl-6-bromo-5-methoxyindoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-(6-Bromo-5-hydroxy-2,3-dihydro-1H-indol-1-yl)ethan-1-one | HCID 21948380 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Acetyl-6-bromo-5-methoxyindoline | HCID 21948375 | 88.1% |
반응 단계
A stirred solution of 1-acetyl-6-bromoindolin-5-ol (Tetrahedron 1973, 29(8), 1115; 40 g, 0.15 mole) in DMF (500 ml) was treated with K2CO3 (61 g, 0.45 mole) and iodomethane (11.7 ml, 0.19 mole) and maintained at room temperature for 20 h, then concentrated under vacuum to 200 ml. The residue was treated with water (200 ml) and the precipitate filtered off, dried and recrystallised from EtOAc to afford the title compound as a white solid (35.7 g, 85%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06747030B1 |
| 출처 데이터셋 | uspto-grants-2004_06 |
| ORD ID | ord-1209a2796f0e4beea1373760462eba3d |
| 출처 메모 | uspto-grants-2004_06 |