6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline → N-(4-acetoxyphenylacetyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

HRID 35242

반응식

HRID 35242 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH2:9][NH:8][CH2:7][CH2:6]2.[C:15]([O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26](Cl)=[O:27])=[CH:21][CH:20]=1)(=[O:17])[CH3:16]>>[C:15]([O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH2:9]2)=[O:27])=[CH:21][CH:20]=1)(=[O:17])[CH3:16]

참가 물질

3

반응물 2

HCID 156236,7-Dimethoxy-1,2,3,4-TetrahydroisoquinolineHCID 182488Benzeneacetyl chloride, 4-(acetyloxy)-

생성물 1

HCID 21295827N-(4-acetoxyphenylacetyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

실험 절차

Using the procedure described in Example 12, 15.0 g of 1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline was reacted with 4-acetoxyphenylacetyl chloride to give 13.0 g of N-(4-acetoxyphenylacetyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline.

출처 및 근거

ORD 기록
ord-25ebba0f0ad9463a8279cd0133e1a0db
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766131

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